澳门拉斯维加斯平台_拉斯维加斯3499线路

 
学校主页
网站首页    
学院新闻
学生工作
通知公告
学术报告
学术前沿
党员之家
先锋行动
学术动态
飘窗新闻


当前位置: 网站首页 学术动态 正文
姜耀甲教授课题组在Chemical Communications发表研究论文
 添加时间:2020/08/21 发布:

Stereoselective Synthesis of Trifluoromethylsubstituted 2H-furan-amines from Enaminones


Xiaoyu Liang,a Pan Guo,a Wenjie Yang,a Meng Li,a Chengzhou Jiang,a Wangbin Sun,a Teck-Peng Loh *ab and Yaojia Jiang*a


a Institute of Advanced Synthesis, Nanjing Tech University, Nanjing 211816, P. R. China.

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637616, Singapore.


Abstract:A straightforward strategy for synthesis of highly functionalized trifluoromethyl 2H-furans is described. The copper catalyzed method relies on a cascade cyclic reaction between enaminones and N-tosylhydrazones. This method allows the synthesis of 2-amino-3-trifluoromethyl-substituted 2H-furan derivatives carrying a quaternary stereogenic center as single diastereomers. The proposed reaction mechanism involves an amino-cyclopropane intermediate formed in the cyclopropanation of enaminones. The developed method tolerates a broad spectrum of functionalities, and the obtained 2H-furan derivatives are useful synthetic intermediates for preparing other trifluoromethylsubstituted compounds.

Chem. Commun. DOI: 10.1039/c9cc08582c (2019年影响因子:6.164)

文章链接:https://pubs.rsc.org/en/content/articlelanding/2020/CC/C9CC08582C#!divAbstract

 


地址:南京浦口区浦珠南路30号 邮编:211880 电话:025-58139535、9536、9537 邮箱:chem@njtech.edu.cn
Copyright (C) 2020 澳门拉斯维加斯平台_拉斯维加斯3499线路 All rights reserved.
总共访问: 今日访问: